2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P4157A
    FOXO4-DRI acetate 98%
    FOXO4-DRI acetate is a cell-permeable peptide antagonist that blocks the interaction of FOXO4 and p53. FOXO4-DRI acetate is a senolytic peptide that induces apoptosis of senescent cells.
    FOXO4-DRI acetate
  • HY-P5161A
    FC382K10W15 TFA 98%
    FC382K10W15 TFA is a glucagon analogue and GLP-1R/GCGR agonist. FC382K10W15 TFA can be used in type 2 diabetes research.
    FC382K10W15 TFA
  • HY-P5578A
    A8SGLP-1 TFA 98%
    A8SGLP-1 TFA is an orally active GLP-1 analogue that the alanine at position 8 substituted with serine. A8SGLP-1 TFA reduces blood glucose in db/db mice without affecting its function.
    A8SGLP-1 TFA
  • HY-P5762A
    Phoenixin-14 TFA 98%
    Phoenixin-14 (PNX-14) TFA, a neuropeptide, has anxiolytic, cardioprotective and neuroprotective effect. Phoenixin-14 TFA can regulate pituitary gonadotrophin secretion by upregulating the GnRH receptor mRNA. Phoenixin-14 TFA stimulates insulin secretion. Phoenixin-14 TFA also protects mice from ischemia/reperfusion (IR) injury. PNX-14 TFA prevents oxidative stress by reducing ROS and increasing GSH.
    Phoenixin-14 TFA
  • HY-U00430
    MGAT2-IN-2 1710630-11-7 98%
    MGAT2-IN-2 is a potent and selective acyl CoA:monoacylglycerol acyltransferase 2 (MGAT2) inhibitor with an IC50 of 3.4 nM.
    MGAT2-IN-2
  • HY-Y0035R
    4,4-Dimethoxy-2-butanone (Standard) 5436-21-5
    4,4-Dimethoxy-2-butanone (Standard) is the analytical standard of 4,4-Dimethoxy-2-butanone. This product is intended for research and analytical applications. 4,4-Dimethoxy-2-butanone is an endogenous metabolite.
    4,4-Dimethoxy-2-butanone (Standard)
  • HY-Y0061R
    Oxindole (Standard) 59-48-3
    Oxindole (Standard) is the analytical standard of Oxindole. This product is intended for research and analytical applications. Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.
    Oxindole (Standard)
  • HY-Y0106R
    2,6-Dihydroxyacetophenone (Standard) 699-83-2
    2,6-Dihydroxyacetophenone (Standard) is the analytical standard of 2,6-Dihydroxyacetophenone (HY-Y0106). This product is intended for research and analytical applications. 2,6-Dihydroxyacetophenone, a polyphenolic derivative of Acetophenone (HY-Y0989), is an orally active mTOR inhibitor. 2,6-Dihydroxyacetophenone shows antioxidant activity. 2,6-Dihydroxyacetophenone inhibits cell growth and proliferation in CRC cells. 2,6-Dihydroxyacetophenone arrests at G0/G1 phase of cell cycle, induces apoptosis and suppresses cell migration in CRC cells. 2,6-Dihydroxyacetophenone inhibits xanthine oxidase (XOD) with an IC50 of 1.24 mM. 2,6-dihydroxyacetophenone improves uric acid metabolism in hyperuricemia mice, reduces plasma cholesterol in hypercholesterolemic rats, and inhibits lipid accumulation in HFD-induced obese mice. 2,6-Dihydroxyacetophenone can be used for the study of colorectal cancer (CRC), hyperuricemia and hypercholesterolemia.
    2,6-Dihydroxyacetophenone (Standard)
  • HY-Y0136R
    3-Indoleacetonitrile (Standard) 771-51-7
    3-Indoleacetonitrile (Standard) is the analytical standard of 3-Indoleacetonitrile. This product is intended for research and analytical applications. 3-Indoleacetonitrile is an indole derivative with anti-influenza activity. 3-Indoleacetonitrile is a plant hormone produced by cruxiferous vegetables. 3-Indoleacetonitrile exerts profound antiviral activity against a broad spectrum of influenza A viruses, HSV-1 and VSV viruses in vitro. 3-Indoleacetonitrile diminishes lung virus titers and alleviates lung lesions in vivo. 3-Indoleacetonitrile induces an increase in mitochondrial antiviral-signaling (MAVS) protein levels. 3-Indoleacetonitrile can be used in research for combating viral infections including COVID-19, HSV-1, and VSV.
    3-Indoleacetonitrile (Standard)
  • HY-Y0152A
    Cinchonine monohydrochloride hydrate 206986-88-1 98%
    Cinchonine ((8R,9S)-Cinchonine) monohydrochloride hydrate is a natural compound which has been effectively used as antimalarial agent. Cinchonine monohydrochloride hydrate activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells. Cinchonine monohydrochloride hydrate is also an inhibitor of human platelet aggregation. Cinchonine monohydrochloride hydrate possesses a suppressive effect on adipogenesis.
    Cinchonine monohydrochloride hydrate
  • HY-Y0191R
    α-Pyridone (Standard) 142-08-5
    α-Pyridone (Standard) is the analytical standard of α-Pyridone. This product is intended for research and analytical applications. α-Pyridone (2-Pyridone) is an antibacterial agent. α-Pyridone can be synthesized via the 1,4-addition of 2-(phenylsulfinyl)acetamide to α,β-unsaturated ketones followed by cyclization and sulfoxide elimination. α-Pyridone can also be used to synthesize a wide range of heterocyclic compounds.
    α-Pyridone (Standard)
  • HY-Y0262A
    Oxalic acid diammonium monohydrate 6009-70-7 ≥98.0%
    Oxalic Acid is a strong dicarboxylic acid occurring in many plants and vegetables and can be used as an analytical reagent and general reducing agent.
    Oxalic acid diammonium monohydrate
  • HY-Y0289S
    1-Dodecanol-13C 88170-32-5 98%
    1-Dodecanol-13C is the 13C-labeled 1-Dodecanol. 1-Dodecanol is an endogenous metabolite.
    1-Dodecanol-13C
  • HY-Y0399S
    L-Norvaline-d5 1202936-50-2 98%
    L-Norvaline-d5 is the deuterium labeled L-Norvaline. L-Norvaline is the inhibitor for arginase, that promotes the production of NO, reduces oxidative stress, improves insulin resistance, and exhibits antioxidant and anti-hyperglycemic effects. L-Norvaline can be used in research of Alzheimer’s disease.
    L-Norvaline-d5
  • HY-Y0442S
    2-Methylbenzaldehyde-13C 138151-99-2 98%
    2-Methylbenzaldehyde-13C is the 13C labeled 2-Methylbenzaldehyde. 2-Methylbenzaldehyde is an endogenous metabolite.
    2-Methylbenzaldehyde-13C
  • HY-Y0444S
    D-Tyrosine-d2 1202064-22-9 98%
    D-Tyrosine-d2 is the deuterium labeled D-Tyrosine (HY-Y0444). D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth.
    D-Tyrosine-d2
  • HY-Y0504S
    Trimethylammonium chloride-13c3,d9 2483824-12-8 98%
    Trimethylammonium chloride-13C3,d9 is the deuterium and 13C labeled Trimethylammonium chloride. Trimethylammonium chloride is an endogenous metabolite.
    Trimethylammonium chloride-13c3,d9
  • HY-Y0624R
    4-Pentenoic acid (Standard) 591-80-0
    4-Pentenoic acid (Standard) is the analytical standard of 4-Pentenoic acid (HY-Y0624). This product is intended for research and analytical applications. 4-Pentenoic acid is a medium-chain unsaturated fatty acid. 4-Pentenoic acid has hypoglycemic and fatty acid oxidation inhibitory activities. 4-Pentenoic acid can affect blood glucose metabolism and energy metabolism through mechanisms such as inhibiting long-chain fatty acid oxidation, reducing gluconeogenesis, and promoting glucose utilization.
    4-Pentenoic acid (Standard)
  • HY-Y0740R
    4-Methoxybenzaldehyde (Standard) 123-11-5
    4-Methoxybenzaldehyde (Standard) is the analytical standard of 4-Methoxybenzaldehyde. This product is intended for research and analytical applications. 4-Methoxybenzaldehyde (p-anisaldehyde) is a fragrant phenolic compound. 4-Methoxybenzaldehyde has been found in many plant species including horseradish, anise, star anise. 4-Methoxybenzaldehyde is a possible neurotoxicant and it has shown effects that include mortality, attractancy, and interference with host seeking .
    4-Methoxybenzaldehyde (Standard)
  • HY-Y0836R
    Diethyl succinate (Standard) 123-25-1
    Diethyl succinate (Standard) is the analytical standard of Diethyl succinate. This product is intended for research and analytical applications. Diethyl succinate (Diethyl Butanedioate) can be utilized at physiological pH, allowing it to penetrate biological membranes and integrate into the cells of tissue cultures, where it is metabolized via the tricarboxylic acid cycle. Diethyl succinate modulates the polarization and activation of microglial cells by reducing mitochondrial fission and the levels of reactive oxygen species (ROS), thereby exerting an inflammatory protective effect in primary microglial cells. Furthermore, Diethyl succinate is non-toxic and can be used in flavorings and seasonings.
    Diethyl succinate (Standard)
Cat. No. Product Name / Synonyms Application Reactivity